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41. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-2007_executive.pdf
    January 01, 2007 - Layout 1 Background Rheumatoid and psoriatic arthritis are among the most disabling forms of arthritis. Rheumatoid arthritis (RA), which affects 1 percent of the U.S. adult population (or upwards of 2 million individuals), is an autoimmune disease that involves inflammation of the synovium (a thin layer of tissue lin…

42. EHC Protocol: Making Healthcare Safer IV: Deprescribing to Reduce Medication Harms in Older Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/deprescribing-protocol.pdf
    July 01, 2023 - drug events (ADEs), increased healthcare utilization (e.g., emergency department visits, acute care … drug events, adverse drug withdrawal events, mortality) Implementation measures (e.g., barriers … Adverse drug events in ambulatory care. … Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting. … Reducing Adverse Drug Events in Older Adults.

43. Evidence Report on the (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-adults_research-protocol.pdf
    December 01, 2010 - National Library of Medicine’s TOXLINE® database and the MedEffectTM Canada Adverse Drug Reaction Database

44. CER 218 Disposition of Comments: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-218-osteoporosis-disposition-comments.pdf
    April 23, 2019 - Statements about the risk of potential adverse drug reactions are made without the rigor that is applied … Esophageal cancer is not a class specific adverse drug reaction for either bisphosphonates or denosumab … increased fracture risk) and hypothetical benefits (reduced risk of AFFs, ONJ and other potential adverse … drug reactions) of discontinuing treatment with a bisphosphonate after 3 to 5 years (i.e., taking

45. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/ace-inhibitor-arb-update_executive.pdf
    June 01, 2011 - Layout 1 Background Almost 75 million American adults— approximately one-third—have hypertension. The prevalence of hypertension increases with advancing age such that more than half of people 55 to 74 years old and approximately three-fourths of those age 75 years and older are affected. In addition to being the pr…

46. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/juvenile-arthritis-dmards_executive.pdf
    September 01, 2011 - Layout 1 Background Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in childhood, with an overall prevalence of 7 to 400 per 100,000 children. JIA is an important cause of chronic disease in childhood, with prevalence similar to type I diabetes mellitus. Several classification systems ha…

47. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/thromboembolism-update-executive-170622.pdf
    June 01, 2017 - Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update Comparative Effectiveness Review Number 191 Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update Executive Summary Introduction Major orthopedic surgery carries a high risk for venous …

48. Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/thromboembolism-update-executive-170622.pdf
    June 01, 2017 - Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update Comparative Effectiveness Review Number 191 Venous Thromboembolism Prophylaxis in Major Orthopedic Surgery: Systematic Review Update Executive Summary Introduction Major orthopedic surgery carries a high risk for venous …

49. Management of Primary Headache During Pregnancy: Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/headaches-pregnancy.pdf
    March 23, 2019 - OR “Tetracyclic antidepressant” OR mirtazapine OR “Somatostatin analog” OR octreotide) AND ("drug-related … side effects and adverse reactions"[MESH] OR “abnormalities, drug- induced”[MESH] OR birth defect OR

50. Management of Primary Headache During Pregnancy | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/headaches-pregnancy/protocol
    November 12, 2019 - lithium OR “Tetracyclic antidepressant” OR mirtazapine OR “Somatostatin analog” OR octreotide) AND ("drug-related … side effects and adverse reactions"[MESH] OR “abnormalities, drug-induced”[MESH] OR birth defect OR

51. Evidence Summary for CER 239: Acute Treatments for Episodic Migraine (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-239-acute-migraine-evidence-summary.pdf
    December 01, 2020 - Evidence Summary for CER 239: Acute Treatments for Episodic Migraine Comparative Effectiveness Review Number 239 Acute Treatments for Episodic Migraine Evidence Summary Main Points • Compared with placebo, treatments such as triptans, NSAIDs (nonsteroidal anti- inflammatory drugs), dihydroergotamine, antieme…

52. Making Healthcare Safer IV_Rapid Response_Deprescribing To Reduce Medication Harms in Older Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-rapid-response-deprescribing.pdf
    February 01, 2024 - drug event; ADWE = adverse drug withdrawal event; CI = confidence interval; ED = emergency department … Adverse drug events in ambulatory care. … Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting. … Reducing Adverse Drug Events in Older Adults. … Drug Events in Older Adults.

53. CER 215 Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-215-depression-older-adults-comments.pdf
    March 28, 2019 - CER 215 Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults Comparative Effectiveness Review Disposition of Comments Report Research Review Title: Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults Draft review available for public comment fr…

54. Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/atypical-antipsychotics-off-label-update/research-protocol
    May 19, 2010 - Current Page Topic Timeline May. 19, 2010 Research Protocol Jun. 1, 2011 Topic Suggestion Sep. 27, 2011 Systematic Review Jan. 12, 2012 Disposition of Comments Report Jul. 5, 2016 Surveillance Report Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update Research Protocol Archi…

55. Psoriatic Arthritis Surveillance Assesment_CER 54_Low (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/arthritis-psoriatric_surveillance.pdf
    March 01, 2013 - Psoriatic Arthritis Surveillance Assesment_CER 54_Low CER #54: Drug Therapy for Psoriatic Arthritis in Adults: Update of a 2007 Report Original release date: June 2012 Surveillance Report: March 2013 Key Findings: - Key Question 1: Conclusion regarding biologic Disease- Modifying Antirheumatic D…

56. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-update_research-protocol.pdf
    May 07, 2010 - Evidence-based Practice Center Systematic Review Protocol Source: www.effectivehealthcare.ahrq.gov Published Online: May 07, 2010 Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors (ACEIs) …

57. Dietary Supplements in Adults Taking Cardiovascular Drugs | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/dietary-supplements/research
    April 30, 2012 - Current Page Topic Timeline Apr. 1, 2009 Topic Suggestion Dec. 21, 2010 Research Protocol Apr. 30, 2012 Systematic Review Jul. 3, 2013 Surveillance Report Dietary Supplements in Adults Taking Cardiovascular Drugs Systematic Review Archived April 30, 2012 Web Version [NLM Site] Download Main Document PDF 6.8 MB …

58. Treatments for Acute Pain | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/treatments-acute-pain/research
    December 29, 2020 - Treatments for Acute Pain: A Systematic Review Systematic Review December 29, 2020 Download Main Document PDF 3.3 MB Related Files Download Evidence Summary [PDF · 298.3 KB] Download Appendix E [XLSX · 151.1 KB] Download Appendix F [XLSX · 28.2 KB] Download Disposition of Comments Report [PDF · 1.2 MB…

59. Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
    April 01, 2020 - Nonopioid Pharmacologic Treatments for Chronic Pain: Evidence Summary Purpose of Review Evaluate the benefits and harms of nonopioid drugs in randomized controlled trials of patients with spe- cific types of chronic pain, considering the effects on pain, function, quality of life, and adverse events. Key Messages…

60. Treatments for Adults with Schizophrenia: A Systematic Review (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/schizophrenia-adult_research-protocol.pdf
    September 23, 2016 - Treatments for Adults with Schizophrenia: A Systematic Review Source: www.effectivehealthcare.ahrq.gov Published online: September 23, 2016 Evidence-based Practice Center Systematic Review Protocol Project Title: Treatments for Adults with Schizophrenia: A Systematic Review Initial publication date: August …